5-HTP (5-Hydroxytryptophan)

What it is: A naturally occurring amino acid and direct precursor to serotonin, the neurotransmitter that regulates mood, sleep, appetite, and emotional balance.

Why we use it: 5-HTP is commonly used in supplements to support mood, stress resilience, and sleep quality, especially in those with signs of low serotonin.

  • May Reduce Neuroinflammation via Serotonin Modulation - Healthy serotonin levels are associated with lower inflammatory markers in the brain, supporting resilience under chronic stress.
  • Combats Brain Fog Linked to Low Mood - Mood and cognition are deeply linked—improving serotonin may reduce mental sluggishness and low motivation often seen with mood disorders.
  • Improves Sleep-Dependent Brain Function - By improving sleep (especially REM and deep sleep), 5-HTP can enhance memory consolidation, mood regulation, and next-day mental clarity. Serotonin is the precursor to melatonin, the sleep hormone—so 5-HTP can support better sleep onset and depth, especially in people with poor melatonin conversion.
  • Supports Healthy Serotonin Levels - Serotonin is key to emotional balance, motivation, and a sense of well-being. Low serotonin is linked to anxiety, depression, insomnia, and even cognitive fatigue.
  • Boosts Mood & Emotional Well-being - Increases serotonin levels, which can help alleviate low mood, irritability, and emotional fatigue. Often used to support people with mild to moderate depression or mood swings.
  • Reduces Stress and Anxiety - Higher serotonin helps regulate the stress response and blunt overactive emotional reactions, reducing feelings of overwhelm or tension.
  • Possible Natural Alternative to SSRIs - May provide mild serotonin support for those looking for non-pharmaceutical mood balancing tools, especially when used medical provider under guidance.
  • Supports Appetite Control & Cravings - Helps reduce carbohydrate cravings and emotional eating, especially during times of stress or hormonal shifts. Can assist in weight management plans.
  • Pairs Well with Other Brain-Calming Nutrients - Combines well with B6 (for serotonin conversion), magnesium, GABA, theanine, and calming herbs to balance stimulation and mood.

What is it in: SleepSync (coming soon)

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Apigenin

What it is: A powerful plant flavonoid found in things like chamomile, parsley, and celery.

Why we use it: It's often taken for sleep and relaxation, its effects go far beyond that—especially in neuroprotection, mood regulation, and cellular aging. It's a rising star in both sleep stacks and longevity protocols.

  • Neuroprotection - Protects brain cells from oxidative damage and neuroinflammation. May be helpful for age-related cognitive decline, especially when combined with other nootropics or adaptogens.
  • May Improve Sleep Architecture - Helps you fall asleep more easily and promotes deep, restful sleep, especially when taken before bed. Enhances slow-wave (deep) sleep, helping with memory consolidation and brain detox (via glymphatic flow). Ideal for people who sleep but don’t feel rested. Often stacked with magnesium, theanine, or glycine in sleep blends.
  • Supports Calm Focus & Emotional Balance - Binds to GABA-A receptors (just like calming neurotransmitters), enhancing GABAergic tone, which can help reduce anxiety, quiet overthinking, and promote mental stillness. Creates a soothing, anxiolytic effect without sedation. Similar in feel to a cup of chamomile tea—only stronger and more targeted. Useful in both daytime stress support and nighttime sleep rituals.
  • Synergy with Magnesium and Theanine - These three work in harmony to enhance calm, protect neurons, and optimize sleep—without harsh sedatives or brain fog the next day.
  • Balances Stress Hormones in the Brain - Reduces CRH (corticotropin-releasing hormone) and HPA axis overactivity—making it useful for people with stress-related brain fog or burnout. Shown to lower cortisol levels, especially when combined with compounds like magnesium threonate or L-theanine. Ideal for evening wind-down or stress recovery.
  • Supports Cellular Aging and Longevity - Inhibits CD38, an enzyme that depletes NAD+, a key molecule for mitochondrial function and anti-aging. Often included in longevity stacks with NMN or resveratrol.
  • Anti-inflammatory and Antioxidant - Fights oxidative stress and reduces inflammation at the cellular level. May help lower systemic inflammation and support overall health.

What is it in: SleepSync (coming soon)

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Ashwagandha Extract

What it is: Ashwagandha extract (Withania somnifera) is a powerful adaptogen with centuries of use in Ayurvedic medicine, now backed by strong modern research.

Why we use it: Ashwagandha is known for helping the body adapt to stress, improve energy, mood, sleep, and hormone balance, and support overall brain and body resilience.

  • Protects the Brain from Stress Damage - Ashwagandha is neuroprotective—it helps buffer the brain against the harmful effects of cortisol, oxidative stress, and inflammation.
  • May Promote Neurogenesis & Brain Resilience - Some studies suggest ashwagandha can help stimulate nerve growth factor (NGF), supporting long-term brain plasticity and regeneration.
  • Supports Sleep-Dependent Brain Recovery - By improving sleep and reducing cortisol, it allows for better overnight brain detoxification and emotional reset. Supports deeper, more restorative sleep, especially in people with stress-related insomnia. Pairs well with magnesium, GABA, or theanine in sleep stacks.
  • Reduces Anxiety & Improves Mood - Shown to significantly reduce symptoms of anxiety, depression, and chronic stress, likely by modulating GABA and cortisol. Supports a calm, grounded mental state. Ashwagandha helps lower chronically elevated cortisol, which can reduce anxiety, fatigue, belly fat, and brain fog. One of the most effective natural anti-stress compounds—supported by many human studies.
  • Improves Focus and Mental Clarity - Enhances cognitive performance and working memory, especially in chronically stressed individuals.
  • Improves Energy & Reduces Fatigue - Balances adrenal function and may increase mitochondrial energy production, leading to better stamina and reduced burnout. Unlike stimulants, it boosts calm energy without jitteriness.
  • Supports Hormone Balance (Men & Women) - May increase testosterone and fertility in men, while helping balance estrogen/cortisol in women, especially during PMS or perimenopause.
  • Strengthens Immunity - Adaptogens like ashwagandha support immune resilience, especially during long-term stress or fatigue.

What is it in: SleepSync (coming soon)

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Black Pepper Extract (Piperine)

What it is: A natural bioavailability enhancer from black pepper.

Why we use it: Boosts absorption of curcumin and other nutrients for improved efficacy.

  • Helps your body absorb vitamins, minerals, and nutrients better, such as B12, folate, magnesium, K2, curcumin, NAC, D3, etc. for improved efficacy.
  • Anti-Inflammatory and Antioxidant Properties - Piperine has been shown to reduce oxidative stress and inflammation, which can help protect cells throughout the body.
  • Digestive Support - It can stimulate the secretion of digestive enzymes, which may improve digestion and nutrient uptake.
  • Neuroprotection - Black pepper extract has shown promise in protecting brain cells from oxidative damage, which is key in preventing neurodegenerative diseases like Alzheimer's and Parkinson's.
  • Improved Memory and Cognitive Function - Some animal studies suggest piperine may improve memory and cognitive performance by increasing neurotransmitter levels like serotonin and dopamine.
  • Anti-Depressant Effects - Piperine has shown potential to reduce symptoms of depression in preclinical studies by modulating monoamine levels (like serotonin, dopamine, and norepinephrine).
  • Reduces Neuroinflammation - Chronic inflammation in the brain is linked to various cognitive disorders; piperine's anti-inflammatory effects might help reduce this.

What is it in: CerebraD+ (coming soon) & SleepSync (coming soon)

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Chamomile Flower Powder

What it is: One of the oldest and most beloved herbal remedies, known for its soothing, anti-anxiety, and sleep-promoting properties.

Why we use it: Chamomile is used worldwide as a gentle nervous system relaxant and mood soother, with real benefits backed by both tradition and modern science.

  • Neuroprotective Effects - Apigenin and chamomile's antioxidants help protect neurons from oxidative damage, stress, and inflammation, supporting long-term brain health.
  • Enhances Sleep Architecture - Promotes deeper, more restorative sleep—important for overnight memory consolidation, brain detox, and emotional reset. Helps reduce sleep latency (time to fall asleep) and may improve overall sleep depth—especially helpful for those whose insomnia is stress-related.
  • Reduces Anxiety & Emotional Reactivity - Effective in mild-to-moderate generalized anxiety disorder (GAD), according to clinical studies. Helps with overthinking, irritability, and emotional turbulence.
  • Gentle Mood Regulation - Balances neurotransmitters like GABA and serotonin, making it useful for emotional stability without side effects. Promotes calm and relaxation. Chamomile is best known for its mild sedative effects—it gently calms the mind and body without heavy sedation. Great for winding down after a long day or taking the edge off emotional tension.
  • Natural Source of Apigenin - Chamomile contains apigenin, a powerful flavonoid that binds to GABA-A receptors, promoting mental calm, better sleep, and reduced anxiety.
  • Anti-inflammatory and Antioxidant Properties - Contains apigenin, flavonoids, and terpenoids that combat oxidative stress and inflammation systemically and in the brain.
  • Supports Immune Function - Has mild antimicrobial and immune-balancing effects, which can help the body stay resilient during times of physical or mental stress.
  • Soothes Digestive Discomfort - Acts as a carminative herb, reducing bloating, cramping, and GI upset—especially when those issues are linked to anxiety or stress.

What is it in: SleepSync (coming soon)

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Curcumin

What it is: The active compound in turmeric.

Why we use it: Potent anti-inflammatory and antioxidant for cognitive longevity and joint health.

  • May Protect Against Alzheimer’s Disease - Curcumin can cross the blood-brain barrier and may help clear beta-amyloid plaques, one of the hallmarks of Alzheimer’s.
  • Reduces Neuroinflammation - Chronic inflammation in the brain is linked to cognitive decline and diseases like Alzheimer’s. Curcumin helps reduce inflammation in neural tissue.
  • Improved Cognitive Function - Small clinical trials suggest curcumin supplementation may lead to better working memory and attention span in older adults.
  • Boosts Brain-Derived Neurotrophic Factor (BDNF) - BDNF is like fertilizer for your brain—it promotes the growth of new neurons and synapses. Curcumin has been shown to increase BDNF levels, which may support learning, memory, and mood.
  • Antidepressant-Like Effects - Studies have shown curcumin can improve mood, possibly by increasing serotonin and dopamine levels. Some research even compares its effects to pharmaceutical antidepressants (in mild to moderate cases).
  • Powerful Anti-Inflammatory Agent - Curcumin blocks inflammatory pathways (like NF-kB) and helps reduce chronic inflammation, which is a root cause of many diseases.
  • Strong Antioxidant - It neutralizes free radicals and boosts the body's own antioxidant enzymes like glutathione.
  • Joint and Muscle Support - Commonly used to reduce pain and stiffness, especially in conditions like arthritis or post-exercise soreness.
  • Cardiovascular Benefits - Curcumin can improve endothelial function (lining of blood vessels), reduce LDL oxidation, and support overall heart health.
  • Immune System Modulation - It helps regulate immune responses, potentially making it useful in autoimmune or inflammatory disorders.

What is it in: CerebraD+ (coming soon)

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GABA (Gamma-AminoButyric Acid)

What it is: GABA is your brain’s main inhibitory neurotransmitter, and a powerful natural compound for relaxation, stress relief, mood balance, and sleep.

Why we use it: While your brain makes GABA naturally, many people take it in supplement form to calm the nervous system and reduce overstimulation.

  • Protects Against Neuroinflammation & Overload - By calming excessive neural firing, GABA reduces excitotoxicity, which is a key mechanism in neurodegeneration and stress-related brain aging.
  • Regulates Neural Excitability - GABA’s core role is to prevent overexcitation in the brain—crucial for focus, emotional stability, and protection from burnout.
  • Pairs Well with Nootropics & Calming Botanicals - Combines synergistically with L-theanine, magnesium, apigenin, lemon balm, passion flower, and glycine for smoother focus and recovery.
  • Supports Mood & Emotional Stability - Low GABA levels are linked to anxiety, irritability, depression, and insomnia. Supplementing can help restore balance, especially in those with GABAergic deficiencies. GABA is the brake pedal of the brain, helping quiet mental activity and create a feeling of relaxed ease. Great for reducing mental tension without numbing or sedating. Supplementation may help reduce stress reactivity and promote a balanced emotional state, especially in high-pressure situations.
  • Improves Sleep Architecture - Supports deeper stages of sleep (especially slow-wave sleep), which are essential for memory consolidation and brain detox. Helps the body wind down and fall asleep by reducing nervous system excitability. Can lead to deeper, more restful sleep—especially in people who can’t “shut off their brain” at night.
  • Muscle Relaxation - Because it calms the central nervous system, GABA can also ease muscle tension, restlessness, and twitching.
  • May Lower Blood Pressure - Some studies suggest GABA can help reduce blood pressure, especially under stress, likely by enhancing parasympathetic activity.

What is it in: SleepSync (coming soon)

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L-Methylfolate

What it is: Active, bioavailable form of folate (Vitamin B9); no conversion needed—your body can use it immediately.

Why we use it: Crucial for neurotransmitter synthesis, methylation, and cognitive balance.

  • Supports Cognitive Function - Low folate has been linked to poor memory, brain fog, and even dementia. L-methylfolate supports healthy brain aging and memory retention.
  • Critical for Neurotransmitter Production - It’s essential for synthesizing serotonin, dopamine, and norepinephrine—all major mood and motivation-related neurotransmitters. L-methylfolate provides methyl groups needed for neurotransmitter metabolism via the methylation cycle.
  • Improves Mood and Helps with Depression - Used in clinical settings (even prescription form like Deplin®) as an adjunct treatment for depression, especially in people who don’t respond well to SSRIs. Effective in those with low folate levels or MTHFR gene mutations.
  • May Help with ADHD and Cognitive Disorders - Some research suggests it may benefit attention and executive function in those with folate metabolism issues.
  • Reduces Homocysteine - High homocysteine is linked to neurodegeneration. L-methylfolate helps regulate it, which protects the brain over time.
  • Essential for DNA & Cell Repair - Crucial in the production and repair of DNA, red blood cells, and other rapidly dividing cells.
  • Supports Cardiovascular Health - Helps reduce homocysteine levels, an amino acid that, in high amounts, is linked to heart disease and cognitive decline.
  • Immune and Energy Support - Folate is needed for proper immune cell function and energy metabolism.
  • Prenatal and Fertility Support - Ensures proper neural tube development in pregnancy and supports reproductive health in both men and women.

What is it in: Cogni-Clarity

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L-Theanine

What it is: A naturally occurring amino acid found in green tea leaves and a favorite in both calming daytime nootropic stacks and nighttime sleep blends.

Why we use it: It’s known for its unique ability to relax the mind without causing drowsiness, making it a superstar for stress, focus, and sleep quality.

  • Neuroprotection & Longevity - Shows antioxidant and anti-inflammatory properties in the brain. May help protect against cognitive decline, oxidative stress, and age-related damage.
  • Supports Neurotransmitter Balance - Increases calming neurotransmitters like GABA, dopamine, and serotonin. Helps regulate mood and support emotional resilience.
  • Enhances Alpha Brain Waves - Associated with creative thinking, calm focus, and mental clarity. Promotes that “present and clear” feeling without the need for stimulants.
  • Boosts Focus and Attention - Enhances selective attention, especially when under stress or multitasking. Great for ADHD-style distractions, overthinking, or “racing mind.”
  • Protects Brain from Overstimulation - Acts as a glutamate modulator, helping prevent neural overexcitation, which can lead to anxiety or burnout. May reduce symptoms in sensory-sensitive or highly reactive individuals.
  • Promotes Calm Without Sedation - Increases alpha brain waves, the same state associated with meditation, calm focus, and flow. Reduces “mental noise” and creates a sense of alert relaxation.
  • Improves Sleep Quality - Doesn’t knock you out—but helps you fall asleep faster, stay asleep longer, and feel more refreshed. Great addition to melatonin-free or gentle sleep blends.
  • Stress and Anxiety Relief - Modulates cortisol and balances stress hormones, helping reduce the feeling of being “wired but tired.” Often used for situational anxiety (e.g. presentations, travel, exams).
  • Synergizes with Caffeine - When combined with caffeine, it smooths the “jitters” and enhances focused energy without crashes. Popular in nootropic “smart coffee” stacks.
  • Supports Blood Pressure & Heart Rate Regulation - May help reduce blood pressure in high-stress situations by supporting parasympathetic (rest-and-digest) activation.

What is it in: SleepSync (coming soon)

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Lemon Balm Extract

What it is: Melissa officinalis, a soothing herb in the mint family that's been used for centuries to promote relaxation, cognitive clarity, emotional balance, and restful sleep.

Why we use it: It’s often used in stress and sleep supplements, and also shines as a gentle nootropic with mood-lifting properties.

  • Neuroprotection via Antioxidants - The rosmarinic acid in lemon balm helps defend brain cells against oxidative damage and neuroinflammation, which can impair cognition and mood over time.
  • Enhances Cognitive Performance Under Stress - Studies show lemon balm can improve focus, memory, and processing speed, especially in stressful situations or test-taking scenarios.
  • Supports Mood Regulation & Neurotransmitter Balance - May influence acetylcholine and GABA, helping with emotional control, resilience, and a sense of well-being. Can reduce irritability, restlessness, and low mood, especially in people dealing with emotional fatigue or hormonal shifts. Great for PMS, burnout, or post-stress recovery.
  • Improves Sleep-Related Brain Function - By supporting deeper sleep, it helps with overnight memory consolidation, emotional regulation, and mental detox. Helps people fall asleep faster and improves sleep quality, especially when anxiety or a racing mind is the cause of sleeplessness. Pairs beautifully with valerian, passion flower, or theanine.
  • Calms the Overactive Mind - Modulates GABA receptors to quiet mental chatter, reduce restlessness, and support calm clarity. One of the most effective herbal anxiolytics—reduces feelings of nervousness, worry, and agitation. Promotes a gentle sense of calm without impairing mental function.
  • Antioxidant & Anti-inflammatory Properties - Contains rosmarinic acid and other polyphenols that help reduce oxidative stress and inflammation throughout the body and brain.
  • Soothes Digestive Discomfort - Calms the gut-brain axis by relaxing the GI tract and reducing gas, bloating, and cramping often associated with anxiety. Useful in stress-related digestive issues.

What is it in: SleepSync (coming soon)

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Magnesium Glycinate

What it is: Highly bioavailable, well-tolerated magnesium form.

Why we use it: Crucial for neural communication, stress resilience, and muscular relaxation.

  • Neuroprotection - Magnesium can help protect brain cells from excitotoxicity (overactivation of neurons), which is a factor in neurodegenerative conditions like Alzheimer’s and Parkinson’s.
  • Supports Cognitive Function - Magnesium plays a role in synaptic plasticity, which is critical for learning and memory. Low magnesium levels are linked to brain fog, difficulty concentrating, and even age-related cognitive decline.
  • Reduces Anxiety and Calms the Nervous System - Magnesium regulates the hypothalamic-pituitary-adrenal (HPA) axis and GABA receptors (your brain’s calming neurotransmitter), which helps reduce feelings of stress and anxiety. Glycine itself also acts as a calming neurotransmitter.
  • May Help with Depression - Magnesium deficiency has been linked to increased rates of depression. Supplementation may help improve mood, especially in those who are deficient.
  • Improves Sleep Quality - Magnesium glycinate promotes deeper, more restful sleep—which is directly tied to better memory consolidation, emotional regulation, and overall cognitive performance. Glycine (the amino acid it's paired with) also promotes relaxation and deeper sleep, making this form ideal as a nighttime supplement.
  • Highly Bioavailable - Magnesium glycinate is chelated—meaning it's bound to the amino acid glycine—which makes it more absorbable and less likely to cause digestive issues like diarrhea (unlike magnesium citrate or oxide).
  • Muscle Relaxation & Recovery - Helps prevent cramps, spasms, and tightness—commonly used for muscle recovery after workouts or for people with restless legs.
  • Heart & Metabolic Support - Magnesium supports healthy blood pressure, blood sugar regulation, and heart rhythm.
  • Hormonal Balance - Especially helpful for women dealing with PMS symptoms, perimenopause, or hormone-related anxiety and sleep issues.

What is it in: CerebraD+ (coming soon) & SleepSync (coming soon)

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MCT Oil (C8 Caprylic Acid)

What it is: A highly efficient brain fuel derived from coconut oil.

Why we use it: Helps with absorption of vitamins such as D3 and K2; helps deliver clean mental energy and focus.

  • May Help in Neurodegenerative Conditions - Early research suggests ketones from MCT may support cognition in Alzheimer’s disease and other neurological disorders, where glucose metabolism in the brain is impaired.
  • Neuroprotective Effects - Ketones may protect neurons from oxidative stress and help maintain synaptic function, important for long-term brain health.
  • May Improve Cognitive Performance - Studies suggest MCT (especially C8) can enhance memory, focus, and processing speed, even in people with mild cognitive impairment.
  • Clean, Fast Brain Fuel - C8 is converted into ketones within minutes. Ketones are a more efficient, anti-inflammatory fuel source for the brain than glucose. Especially useful during mental fatigue, brain fog, or fasting.
  • Mood & Mental Clarity - Many users report improved mood and “mental sharpness” within 15–30 minutes of taking pure C8 oil.
  • Better Absorption of Fat-Soluble Nutrients - Helps with absorption of vitamins A, D, E, and K—especially when taken alongside food or fat-soluble supplements like curcumin.
  • Rapid Energy Source - C8 is quickly converted into ketones—an alternative energy fuel for your brain and body—without needing glucose or insulin.
  • Supports Fat Burning & Metabolism - Boosts thermogenesis (your body’s calorie-burning process), which may aid in weight management. Helps promote satiety and reduce cravings, especially when taken with meals or in coffee.
  • Gut Health Benefits - C8 may help support a healthy gut microbiome and has mild antimicrobial properties (potentially helpful for candida overgrowth or SIBO).
  • No Crash Energy - Unlike sugar or caffeine, C8 provides a steady energy lift without stimulating the nervous system.

What is it in: CerebraD+ (coming soon)

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Methylcobalamin (Vitamin B12)

What it is: The biologically active form of Vitamin B12; no need for conversion—your body can use it right away. Ideal for people with MTHFR gene mutations or impaired methylation.

Why we use it: Supports neurological function, red blood cell production, DNA synthesis, and brain energy metabolism.

  • Protects Against Brain Atrophy - High-dose methylcobalamin is being studied for its neuroprotective effects in conditions like Alzheimer’s, Parkinson’s, and multiple sclerosis. When paired with L-methylfolate and NAC, methylcobalamin can help reduce homocysteine levels, which are linked to brain shrinkage and cognitive decline.
  • Improves Cognitive Function - Helps with mental clarity, memory, focus, and alertness—especially in people who are B12 deficient.
  • Critical for Nerve Health - Methylcobalamin helps repair the myelin sheath—the protective coating around your nerves—supporting faster and healthier communication between neurons.
  • Mood & Mental Health Support - Essential in the production of dopamine, serotonin, and norepinephrine. Low B12 is strongly associated with depression, irritability, and anxiety.
  • May Help with Sleep-Wake Cycles - B12 helps regulate melatonin production and circadian rhythms. Some people use it to improve wakefulness, especially when taken in the morning.
  • Boosts Energy Production - Supports mitochondrial function and ATP production. Often used to reduce fatigue, especially in people with B12 deficiency or chronic fatigue syndrome.
  • Supports Red Blood Cell Formation - Helps prevent or treat megaloblastic anemia, which can cause tiredness, weakness, and pale skin.
  • Metabolism and Detox Support - Plays a role in the methylation cycle, which is crucial for detoxifying homocysteine and maintaining healthy liver and cardiovascular function.
  • Immune System Support - B12 is involved in immune cell production and repair, helping maintain resilience against illness.

What is it in: Cogni-Clarity

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N-Acetylcysteine (NAC)

What it is: Stable form of cysteine, a precursor to glutathione.

Why we use it: NAC is a powerhouse antioxidant precursor that works at the cellular level to support detox, brain health, mood, and immune function. It’s a favorite in functional medicine, psychiatry, and nootropic stacks for good reason.

  • Neuroprotection & Cognitive Support - NAC’s antioxidant and anti-inflammatory actions may slow or protect against age-related cognitive decline and diseases like Alzheimer’s and Parkinson’s.
  • May Help with Brain Fog and Mental Fatigue - Especially in cases related to inflammation, stress, or post-viral issues (like long COVID or chronic fatigue syndrome).
  • Protects the Brain from Oxidative Stress - Glutathione is crucial for neuronal defense. NAC helps buffer the brain against toxins, inflammation, and oxidative stress that lead to neurodegeneration.
  • Used in Psychiatry for Depression, OCD, and Bipolar Disorder - Clinical studies have shown that NAC supplementation can improve resilience, emotional regulation, and compulsive behavior, particularly when paired with standard treatments.
  • May Improve Mood & Reduce Anxiety - NAC helps regulate glutamate, a major excitatory neurotransmitter. By modulating glutamate levels, it may help calm overactive brain circuits involved in anxiety, OCD, and even PTSD. It also supports dopamine regulation, which can boost mood and motivation.
  • Glutathione Booster - NAC is a precursor to glutathione, your body’s master antioxidant. This helps detoxify cells, fight oxidative stress, and support overall cellular health.
  • Antioxidant Defense - Neutralizes free radicals and protects cells from oxidative damage—a major contributor to aging and chronic disease.
  • Liver & Detox Support - Commonly used to protect the liver from toxins and medications (like acetaminophen overdose). Supports phase II liver detox, helping the body clear out heavy metals, pollutants, and alcohol byproducts.
  • Respiratory Health - Acts as a mucolytic—thins and loosens mucus in the lungs—making it helpful for asthma, COPD, bronchitis, and even long-COVID symptoms.
  • Immune Function - Supports a healthy immune response, and may enhance the function of white blood cells. Often used preventively during cold and flu season.

What is it in: Cogni-Clarity

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Passion Flower Extract

What it is: From Passiflora incarnata, a beautiful, calming botanical known for its anti-anxiety, sleep-promoting, and nervous system-soothing properties.

Why we use it: It’s one of the gentler herbal sedatives, often included in stress support and sleep formulas, especially for those who are mentally overstimulated or emotionally restless.

  • Protects Against Neuroinflammation - Contains flavonoids and alkaloids with antioxidant properties that may protect neurons from oxidative stress and inflammation.
  • Enhances Sleep Architecture - Promotes faster sleep onset and improved sleep quality, especially in people whose insomnia is caused by stress or mental overactivity. By promoting deep sleep, passion flower supports memory consolidation, brain detoxification, and emotional regulation. Works great in melatonin-free blends as a calming agent.
  • Modulates GABA in the Brain - Increases GABA levels, helping inhibit excessive brain activity, calm the nervous system, and reduce mental overstimulation.
  • Reduces Cortisol and Stress Reactivity - May dampen the HPA axis response to stress, which protects the brain from the damaging effects of chronic stress hormones like cortisol.
  • Gentle Emotional Regulation - Doesn’t sedate or blunt emotions, but helps with emotional resilience, calm processing, and improved mental stillness—making it great for people with anxiety or ADHD-like traits. Helps quiet the mind and ease racing thoughts—especially useful for people who feel “tired but wired.” Passion flower is most famous for its gentle, natural anxiolytic (anti-anxiety) effects.
  • Balances Mood & Emotional Reactivity - Helps smooth out emotional highs and lows during the day or before bed—often used in formulas for mood swings, PMS, or burnout.
  • Supports Heart Rate & Blood Pressure Under Stress - May help reduce heart palpitations and mild hypertension associated with stress and anxiety.
  • Muscle Relaxant Properties - Has mild spasmolytic effects that can help relieve muscle tension, headaches, and menstrual cramps. Useful for relaxing both body and mind before bed.

What is it in: SleepSync (coming soon)

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Trimethylglycine (TMG)

What it is: Also known as betaine, a methyl donor molecule.

Why we use it: TMG is a lesser-known but super important compound for methylation, liver health, and brain function. It's especially relevant when you're taking methylated B vitamins like L-methylfolate and methylcobalamin, as TMG can help balance the whole methylation system by supporting healthy homocysteine levels, liver function, and cognitive resilience.

  • Neuroprotection - Emerging research suggests TMG may reduce oxidative stress in the brain and support overall brain cell resilience.
  • Supports Healthy Methylation in the Brain - Methylation is essential for neurotransmitter production, DNA/myelin repair, detoxification, neurotransmitter production, and gene expression. By donating methyl groups in the body, TMG helps “offload” excess methylation stress from L-methylfolate and methylcobalamin, creating a balanced, sustainable methylation cycle.
  • Reduces Homocysteine - Elevated homocysteine is neurotoxic and associated with cognitive decline, Alzheimer’s, and stroke risk. TMG helps lower homocysteine levels naturally by working alongside folate and B12 to regulate the homocysteine cycle, helping convert excess homocysteine into methionine (which supports energy and tissue repair).
  • Synergizes with B-Vitamins - TMG is especially important if you’re supplementing with high-dose methylfolate or methylcobalamin, as it prevents “overmethylation” symptoms (like anxiety, irritability, or insomnia) in sensitive individuals.
  • May Improve Mood and Mental Clarity - By supporting dopamine, serotonin, and norepinephrine synthesis, TMG may enhance mood and focus—especially in people with sluggish methylation or mood disorders.
  • Liver Function & Detoxification - Supports liver cell function and helps protect against fatty liver disease. Promotes bile flow and assists with phase II liver detox, especially when under toxic load (alcohol, medications, pollution, etc.).
  • Cardiovascular Health - Helps lower homocysteine levels, which is a risk factor for heart disease when elevated.
  • Muscle Performance - Some studies suggest TMG may improve muscular strength and endurance, possibly by aiding creatine synthesis and enhancing cellular hydration.
  • Digestive Health - As a naturally occurring osmolyte, TMG supports cell hydration and may assist in protecting the gut lining under stress.

What is it in: Homocysteine Clearance

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Valerian Root Extract

What it is: It’s one of the most researched herbal sleep aids and often included in natural sleep formulas, calming supplements, and PM blends.

Why we use it: It is a time-tested herbal remedy widely used for sleep, relaxation, and nervous system support.

  • Potential Neuroprotective Effects - Contains valerenic acid and flavonoids, which show antioxidant and anti-inflammatory properties in the brain—helpful for long-term cognitive resilience.
  • Reduces Stress-Induced Cognitive Disruption - May help preserve mental clarity and calm during times of acute stress by modulating cortisol and adrenaline spikes. Reduces the physical agitation and tension that often accompany anxiety or insomnia—great for people who feel jittery or can’t stop tossing and turning.
  • Helps with Sleep-Dependent Memory Consolidation - Promotes deep, restful sleep by improving sleep quality, valerian indirectly supports the brain’s ability to process and store information overnight. Valerian is best known for helping people fall asleep faster and stay asleep longer, without the next-day drowsiness seen in many synthetic sleep aids.
  • Supports GABA Activity in the Brain - Valerian enhances GABA signaling, which helps balance excitation and inhibition in the brain—leading to mental calmness and emotional balance.
  • Balances Brain Chemistry Gently - Unlike pharmaceutical sedatives, valerian doesn’t blunt emotional responsiveness or impair next-day cognition at typical doses—making it great for sensitive individuals.
  • Muscle Relaxation - Has mild spasmolytic effects—can help ease tension headaches, muscle cramps, or body discomfort that makes it hard to sleep.
  • Menstrual & Menopausal Symptom Relief - Some studies show valerian may reduce cramps, irritability, and mood swings associated with PMS or hormonal changes, thanks to its muscle-relaxing and calming effects.

What is it in: SleepSync (coming soon)

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Vitamin B6 (Pyridoxine HCl)

What it is: Vitamin B6 is an underrated but essential vitamin for brain health. Pyridoxine HCL converts to pyridoxal-5'-phosphate (P5P), which is the active form of B6.

Why we use it: Vital for neurotransmitter production, optimal brain metabolism, mood regulation, energy metabolism, and nervous system function.

  • Neuroprotection - P5P (the active form) plays a role in maintaining nerve integrity and synaptic function, potentially supporting brain aging and cognition.
  • Essential for Neurotransmitter Production - B6 is critical in the synthesis of dopamine, serotonin, GABA, epinephrine, and norepinephrine. Without enough B6, your brain can’t properly regulate mood, focus, motivation, and stress responses.
  • Reduces Homocysteine - Like methylfolate and B12, B6 helps convert homocysteine into methionine—lowering risk for cognitive decline, stroke, and dementia.
  • Mood, Anxiety & Depression Support - Low B6 levels have been linked to irritability, depression, anxiety, and brain fog. Supplementation can help improve mood—especially when stacked with L-methylfolate and B12.
  • Supports Sleep & Relaxation - Helps your body produce melatonin from serotonin, which promotes healthy circadian rhythms and restful sleep.
  • Energy Metabolism - B6 is a key player in converting food into fuel by helping metabolize proteins, fats, and carbohydrates. Supports production of ATP, the energy currency of your cells.
  • Hormone Regulation - Helps balance hormones—especially important for women dealing with PMS, mood swings, or menstrual-related anxiety. Involved in estrogen detoxification, which supports overall hormonal harmony.
  • Immune Function - Supports white blood cell production and overall immune resilience.
  • Skin, Hair, and Nail Health - Helps maintain healthy skin tone, reduces acne symptoms (especially hormonal acne), and promotes keratin synthesis.

What is it in: Homocysteine Clearance

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Vitamin D3 (Cholecalciferol)

What it is: The bioactive form of Vitamin D.

Why we use it: Supports immune function, mood regulation, cognitive health, and overall well-being.

  • Neuroprotection - D3 reduces neuroinflammation, protects neurons, and may slow or prevent neurodegenerative diseases. Enhances brain detox pathways and supports blood-brain barrier integrity.
  • Cognitive Function - Vitamin D receptors are found in key brain regions linked to memory, focus, and executive function. Low D3 is linked to cognitive decline, brain fog, and even Alzheimer’s risk in long-term studies.
  • Synergy with Other Brain Nutrients - Works well with omega-3s, magnesium, B vitamins, and NAC to support a calm, resilient, focused mind.
  • Mood Support & Antidepressant Effect - D3 helps regulate serotonin production and receptor sensitivity. Low D3 levels are strongly associated with seasonal affective disorder (SAD), depression, and low motivation. Supplementation has been shown to improve mood, especially in those with low baseline D levels.
  • May Help with Anxiety & Stress Response - Some studies suggest D3 helps regulate the HPA axis, reducing overreactions to stress and improving overall resilience.
  • Inflammation Reduction - D3 can help reduce systemic inflammation, which is crucial for people dealing with autoimmune issues, joint pain, or chronic illnesses.
  • Immune System Strengthening - D3 enhances the body’s ability to fight off infections, regulate inflammation, and modulate autoimmune responses. Plays a major role in both innate and adaptive immunity.
  • Bone & Muscle Health - Helps with calcium absorption and regulates phosphorus—essential for strong bones and preventing fractures or osteopenia. Supports muscle strength and may reduce fall risk in older adults.
  • Hormonal Balance - Acts more like a hormone than a vitamin, with influence over thyroid, testosterone, estrogen, and adrenal function.
  • Skin, Hair & Longevity - Healthy D3 levels are associated with improved skin barrier function, reduced psoriasis symptoms, and may even contribute to longer telomeres (a marker of aging).

What is it in: CerebraD+ (coming soon)

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Vitamin K2 (MK-7)

What it is: Vitamin K2 is an important but often overlooked nutrient for cardiovascular, bone, and brain health. The MK-7 form (menaquinone-7) is the most bioavailable type of K2, staying active in the body for up to 72 hours—making it perfect for daily supplementation.

Why we use it: Supports cardiovascular and cognitive health, especially when paired with Vitamin D3.

  • Neuroprotective Potential - Some studies show K2 may protect neurons against oxidative damage, particularly by reducing calcium dysregulation and inflammation in the brain.
  • Supports Brain Aging & Clarity - Vascular stiffness and poor circulation are major contributors to brain fog, memory issues, and dementia—K2 helps reduce these risks by keeping blood vessels flexible.
  • Vascular Brain Health - Good blood flow = good brain function. K2 helps prevent microvascular calcification, which can impair blood flow to brain tissue and increase risk for stroke or cognitive decline.
  • Synergizes with D3 for Cognitive Support - D3 enhances calcium absorption, while K2 ensures it doesn’t end up in the brain’s blood vessels. The D3 + K2 combo is crucial for safe, effective cognitive and bone support.
  • Mitochondrial Support (Emerging Research) - Some early evidence suggests K2 may help support mitochondrial energy production in neurons—important for mental energy and resilience.
  • Anti-inflammatory Properties - Emerging evidence suggests K2 may help reduce chronic low-grade inflammation, benefiting the cardiovascular system and possibly brain health.
  • Heart and Arterial Health - Activates Matrix Gla Protein (MGP), which prevents calcium buildup in blood vessel walls—helping maintain arterial flexibility and reduce atherosclerosis risk.
  • Bone Strength & Density - Activates osteocalcin, a protein needed to bind calcium into the bone matrix. May improve bone mineral density and reduce fracture risk—especially important when taking higher doses of Vitamin D3 or calcium.
  • Calcium Regulation Master - Directs calcium away from arteries and soft tissues and into bones and teeth—critical for preventing arterial calcification and promoting bone density. Works synergistically with Vitamin D3 to keep calcium in the right places.
  • Supports Dental Health - Helps strengthen enamel and supports remineralization, especially in synergy with D3 and magnesium.

What is it in: CerebraD+ (coming soon)

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